Genome editing with DNA-dependent polymerases

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Gene editing

Nature Biotechnology (2024)Cite this article

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Two CRISPR tools harness DNA-dependent polymerases for genome editing — and may overcome some limitations of prime editors.

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Fig. 1: Schematic of prime editors (PEs), DNA polymerase editors (DPEs) and click editors (CEs).

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Author information

Authors and Affiliations

  1. Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA

    Quinn T. Cowan & Alexis C. Komor

Corresponding author

Correspondence to Alexis C. Komor.

Ethics declarations

Competing interests

A.C.K. is a member of the scientific advisory board of Pairwise Plants, is an equity holder in Pairwise Plants and Beam Therapeutics, and receives royalties from Pairwise Plants, Beam Therapeutics and Editas Medicine via patents licensed from Harvard University. A.C.K.’s interests have been reviewed and approved by the University of California, San Diego in accordance with its conflict of interest policies. Q.T.C. declares no competing financial interests.

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Cite this article

Cowan, Q.T., Komor, A.C. Genome editing with DNA-dependent polymerases. Nat Biotechnol (2024). https://doi.org/10.1038/s41587-024-02372-3

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