Targeting double-stranded nucleic acids using the λExo–pDNA system

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This is a summary of: Fu, S. et al. Bacteriophage λ exonuclease and a 5′-phosphorylated DNA guide allow PAM-independent targeting of double-stranded nucleic acids. Nat. Biotechnol. https://doi.org/10.1038/s41587-024-02388-9 (2024).