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Framework for predicting alloreactivity in hematopoietic cell transplants

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Nature Biotechnology (2024)Cite this article

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The therapeutic principle of allogeneic hematopoietic cell transplantation, one the most common forms of cancer immunotherapy, is alloreactivity, yet its molecular determinants remain largely unknown. An analytical framework now enables personalized assessment of alloreactivity from whole-exome sequencing of donor–recipient pairs, to help with prognostication of disease relapse and immune-mediated complications.

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Fig. 1: A framework for systematic mHAg discovery.
41587 2024 2354 Fig1 HTML

References

  1. Blazar, B. R., Hill, G. R. & Murphy, W. J. Dissecting the biology of allogeneic HSCT to enhance the GvT effect whilst minimizing GvHD. Nat. Rev. Clin. Oncol. 17475–492 (2020). A review of our current understanding of the GvL effect.

    Article  PubMed  PubMed Central  Google Scholar

  2. Shlomchik, W. D. Graft-versus-host disease. Nat. Rev. Immunol. 7340–352 (2007). A review that provides mechanistic insights into GvHD immunobiology.

    Article  CAS  PubMed  Google Scholar

  3. Biernacki, M. A., Sheth, V. S. & Bleakley, M. T cell optimization for graft-versus-leukemia responses. JCI Insight 5e134939 (2020). A review that describes the alloantigenic and antigenic landscapes after transplant as well as strategies to augment the GvL effect.

    Article  PubMed  PubMed Central  Google Scholar

  4. Griffioen, M., van Bergen, C. A. & Falkenburg, J. H. Autosomal minor histocompatibility antigens: how genetic variants create diversity in immune targets. Front. Immunol. 7100 (2016). A review that provides a comprehensive compendium of known mHAgs.

    Article  PubMed  PubMed Central  Google Scholar

  5. Mutis, T., Xagara, A. & Spaapen, R. M. The connection between minor H antigens and neoantigens and the missing link in their prediction. Front. Immunol. 111162 (2020). A review that establishes a fascinating parallelism between neoantigens and mHAgs.

    Article  CAS  PubMed  PubMed Central  Google Scholar

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This is a summary of: Cieri, N. et al. Systematic identification of minor histocompatibility antigens predicts outcomes of allogeneic hematopoietic cell transplantation. Nat. Biotechnol. https://doi.org/10.1038/s41587-024-02348-3 (2024).

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Framework for predicting alloreactivity in hematopoietic cell transplants. Nat Biotechnol (2024). https://doi.org/10.1038/s41587-024-02354-5

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