Dark Light
Genome editing with DNA-dependent polymerases

Technology tamfitronics

  • News & Views
  • Published:

Gene editing

Nature Biotechnology (2024)Cite this article

Subjects

Two CRISPR tools harness DNA-dependent polymerases for genome editing — and may overcome some limitations of prime editors.

This is a preview of subscription content, access via your institution

Access options

Access Nature and 54 other Nature Portfolio journals

Get Nature+, our best-value online-access subscription

24,99 € / 30 days

cancel any time

Subscribe to this journal

Receive 12 print issues and online access

214,86 € per year

only 17,91 € per issue

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Schematic of prime editors (PEs), DNA polymerase editors (DPEs) and click editors (CEs).

References

  1. Anzalone, AV et al. Nature 576149–157 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar

  2. Liu, B. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-01947-w (2024).

    Article  PubMed  Google Scholar

  3. Ferreira da Silva, J. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-024-02324-x (2024).

    Article  PubMed  Google Scholar

  4. Chen, P. J. & Liu, D. R. Night. Rev. The gene. 24161–177 (2023).

    Article  CAS  PubMed  Google Scholar

  5. Nelson, JW et al. Nat. Biotechnol. 40402–410 (2022).

    Article  CAS  PubMed  Google Scholar

  6. Liu, B. et al. Nat. Biotechnol. 401388–1393 (2022).

    Article  CAS  PubMed  Google Scholar

  7. Feng, Y. et al. Protein Cell https://doi.org/10.1093/procel/pwac014 (2022).

    Article  PubMed  PubMed Central  Google Scholar

  8. Yan, J. et al. Nature 628639–647 (2024).

    Article  CAS  PubMed  PubMed Central  Google Scholar

  9. Anzalone, AV et al. Nat. Biotechnol. 40731–740 (2022).

    Article  CAS  PubMed  Google Scholar

  10. Yarnall, M. T. N. et al. Nat. Biotechnol. 41500–512 (2023).

    Article  CAS  PubMed  Google Scholar

  11. Levesque, S., Cosentino, A., Verma, A., Genovese, P. & Bauer, D. E. Nat. Biotechnol. https://doi.org/10.1038/s41587-024-02266-4 (2024).

    Article  PubMed  Google Scholar

  12. Wang, X. et al. Curr. Opin. Biomed. Eng. 28100491 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA

    Quinn T. Cowan & Alexis C. Komor

Corresponding author

Correspondence to Alexis C. Komor.

Ethics declarations

Competing interests

A.C.K. is a member of the scientific advisory board of Pairwise Plants, is an equity holder in Pairwise Plants and Beam Therapeutics, and receives royalties from Pairwise Plants, Beam Therapeutics and Editas Medicine via patents licensed from Harvard University. A.C.K.’s interests have been reviewed and approved by the University of California, San Diego in accordance with its conflict of interest policies. Q.T.C. declares no competing financial interests.

About this article

Technology tamfitronics Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cowan, Q.T., Komor, A.C. Genome editing with DNA-dependent polymerases. Nat Biotechnol (2024). https://doi.org/10.1038/s41587-024-02372-3

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/s41587-024-02372-3

Technology tamfitronics Associated content

Spread the love

Discover more from Tamfis

Subscribe to get the latest posts sent to your email.

Leave a Reply

Discover more from Tamfis

Subscribe now to keep reading and get access to the full archive.

Continue reading

0
YOUR CART
  • No products in the cart.