Personalized molecular glue complexes with desired properties
Technology tamfitronics
- Study Highlight
- Published:
Protein engineering
Nature Biotechnology volume42,web page 571 (2024)Cite this article
31 Accesses
1 Altmetric
Degron tags can feature off swiftly and temporally controlled degradation of proteins the utilization of tiny molecules identified as molecular glues. These molecular glues induce or stabilize protein interactions between a aim protein and a ubiquitin ligase. As examine instruments, molecular glue complexes are restricted by the powerful size of degron tags, which prevents integration in endogenous protein-coding genes. In a ogle printed in ScienceMercer et al. apply a gentle evolution solution to generate molecular glue complexes with high affinities and smaller size, obtaining a compact degron that triggers protein degradation and not using a detectable off-aim results.
Unusual work developed an optimized molecular glue, PT-179, that binds cereblon to feature off protein degradation. Unlike its predecessors, PT-179 does now not degrade off-aim proteins, making it an supreme starting up block to get molecular glue complexes with improved properties.
Right here’s a preview of subscription thunder material, get entry to via your institution
Rating steady of entry to alternatives
Rating steady of entry to Nature and 54 assorted Nature Portfolio journals
Rating Nature+, our easiest-price online-get entry to subscription
24,Ninety 9 /30days
assassinate any time
Subscribe to this journal
Gain 12 print points and online get entry to
214,86 per year
easiest 17,91 per boom
Buy this article
- Aquire on Springer Hyperlink
- Instantaneous get entry to to fleshy article PDF
Costs would per chance be field to local taxes which would be calculated at some stage in checkout
Rights and permissions
About this article
Cite this article
Marchal, I. Personalized molecular glue complexes with desired properties. Nat Biotechnol 42571 (2024). https://doi.org/10.1038/s41587-024-02212-4
Published:
Declare Date:
DOI: https://doi.org/10.1038/s41587-024-02212-4
Discover more from Tamfis
Subscribe to get the latest posts sent to your email.