Pan-KRAS destruction with a single PROTAC
Technology tamfitronics Research Highlight Published: 14 October 2024 Cancer Iris Marchal1 Nature Biotechnology volume42,page 1499 (2024)Cite this article Most small-molecule drugs that target oncogenic Kirsten rat sarcoma virus (KRAS) mutants rely on interactions with variant-specific amino acid residues. However, a wide range of KRAS mutations are prevalent in human cancers, and undruggable variants pose a […]