Tag: Precise

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Precise and versatile genome editing with click editors

TamunofiniarisaJuly 23, 2024Science & Technology

Technology tamfitronics Research Briefing Published: 22 July 2024 Nature Biotechnology (2024)Cite this article Subjects We developed click editors, comprising HUH endonucleases, DNA-dependent DNA polymerases and CRISPR–Cas9 nickases, which together enable programmable precision genome engineering from simple DNA templates. This is a preview of subscription content, access via your institution Access options Access Nature and 54 […]

Precise in vivo RNA base editing with a wobble-enhanced circular CLUSTER guide RNA

TamunofiniarisaJuly 13, 2024Science & Technology

Technology tamfitronics Main Site-directed adenosine-to-inosine (A-to-I) RNA base editing is a very promising technology with a clear path for clinical application1,2. Hydrolytic deamination of A by enzymes of the ADAR family (adenosine deaminases acting on RNA) produces an inosine, which is biochemically interpreted as G in many cellular processes such as splicing or translation and, […]