Removal of TREX1 activity enhances CRISPR–Cas9-mediated homologous recombination
Technology tamfitronics Main Repair of CRISPR–Cas9-induced double-strand breaks (DSBs) occurs by one of two main mechanisms: non-homologous end joining (NHEJ) or homology-directed repair (HDR)1,2,3. The HDR pathway is used to introduce sequences of up to 2–3 kilobases (kb) into the genome that are supplied on an exogenous DNA template. In most human cells, the efficiency […]
